CAREERS

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Principal Scientist: Pharmacologist at Healx
Cambridge, GB

Reference: WEB-PS-02/19 
Location: Cambridge, UK 
Start Date: Immediate preferred 
Salary: Competitive compensation package including share options, subject to experience

Closing Date: 31st March 2019

Healx is a fast-growing Cambridge, UK startup combining computational methods and deep pharmacology expertise to identify existing drugs that may treat rare diseases, enabling treatments to be found at a fraction of the time and cost of traditional drug discovery. There are over 7,000 rare diseases that affect an estimated 350 million people worldwide, most of which lack effective treatment. We work closely with patient groups and charities to understand clinical unmet need and with industry to help them find opportunities for progress in rare diseases.

We're looking for a talented pharmacologist with broad drug development expertise to lead the identification and translation of drug repurposing candidates. This is a key role reporting directly to the CSO with the opportunity to have a major impact during our next phase of growth.

The role

Analyse and filter results from Healx' predictive methods and establish a pharmacological rationale for potential drug repurposing candidates 
Lead the selection of drug candidate molecules from existing drugs (‘repurposed drugs’) based on deep knowledge of disease pathways, mechanisms and drug properties 
Guide their translation through preclinical stages, providing in vitro / in vivo study design input 
Write summary reports for client projects, and for internal projects, including chemical, biochemical, pharmacological, pharmaceutical, pharmacokinetic and medical properties to justify the selection of candidate drugs 
Report directly to the CSO and engage with the Pharmacology Advisory Board to refine and finalise drug repurposing predictions 
Work with bioinformaticians and software engineers developing algorithmic methods and tools, provide pharmacology input for new developments 
Interact with clients (charities and pharmaceutical companies) on pharmacology matters 
Work with CEO and Head of Business Development to generate and maintain long term relationships with Healx partners

Who we're looking for

University Degree (with at least a 2:1) and a postgraduate degree from a top university in Biochemistry/ Pharmacology or related discipline 
Minimum of 5 years of experience as a biochemist/pharmacologist in a pharmaceutical environment or related 
In-depth knowledge of the drug discovery and drug development process from project startup to clinical trials 
Able to demonstrate a strong understanding of disease biology applied to drug discovery ideally including in the oncology therapeutic area 
Experience of pre-clinical study design 
Experience in drug repurposing desirable 
Human disease knowledge, ideally current oncology and neurology clinical practice.




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